Cellular Senescence and Aging Biology
TFEB, Autophagy, and the Aging Kidney's Blind Spot
A new Aging Cell paper on TFEB suppression in septic acute kidney injury connects to a mitochondrial redox review, a failed Alzheimer's trial, and collagen peptide immunology to reveal one pattern: age related failure of lysosomal and mitochondrial quality control is the upstream variable the field keeps treating as background noise.
TFEBautophagyaging kidneymitochondrial dysfunction